Since they're doing a plague house already, I have an idea for a zone:
Nightingales: Blood Splattered Banner
During the siege of Baltimore in the War of 1812, the troops receive a visit from an unfriendly third party. The bombs bursting in air are the least of your problems...
Would go best in San Francisco (since the battle took place in a harbor), lots of fog and light and sound effects to simulate explosions, and US troops and NGs running about. Cannons would line the path, and on the other side of the path would be a NG feasting on a body. And of course, the national anthem would play.
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Alright, here's a house idea:
Vampyr: Inquisition (ok, so this was kind of an idea I saw on HNN years ago, but I thought I'd elaborate it)
The Spanish Inquisition was actually bloodthirsty vampires looking for a fresh supply of "donors," and the notion that vampires are repelled by crucifixes is actually a myth perpetuated by vampires for cover-up purposes.