The Hyatt is the tallest hotel building around and if I'm not mistaking it's the tallest structure on International Drive. With everything around it it isn't intrusive until you are about within 2000 ft of it.From the highway, or from a business parking lot in that immediate vicinity? There's a big difference in being able to see them from the highway (raised a fair bit above normal ground level with a clear path) and seeing it from the actual ground level like a parking lot or sidewalk. You can't see anything from the parking lot in Crossroads (that I've noticed, and I'm there fairly often), which is right next to I-4, however you can indeed see Potter from near the Fenton overpass, but those are two different elevations with very different surroundings.
So maybe my viewpoints on the ground are different but the Skyplex isn't even going to be all that viewable from UOR , the theme parks anyway.