As a guess (and it's my own guess than anything)..if Disney does do a blowout for the 50th in terms of announcing,
Honestly, as an early guess more than anything (and more of a pie-in-the-sky guess)..
DLR - Details on Spider-Man at DCA, perhaps a visual video to show some of the concepts at play, alongside a proper visual of how Runaway Railway will be represented for the Toontown area
WDW - Epcot40 (as mentioned officially by Disney), RnRC (I buy that because of one thing: When Attractions reported it, it was because they actually were invited to the WDI campus as part of DVC), and perhaps an update on MK's plans for Tomorrowland for the 50th
DLPR - Update on the Marvel NY Hotel, WDS Marvel Plans, and perhaps a proper announcement on the SW Attraction (which should likely be the Falcon and not Resistance, unfortunately)
HKDL - Update on the Castle and Frozen area
Shanghai - A new look and timeline for the Zootopia area of the park
TDS - Promote New Fantasyland Tokyo
DCL - A small preview on the progress of Triton
__
I get the impression that this year's going to be light on domestic, outside of the East Coast, and that a lot of focus is going to be put towards both TDS, and DLPR.