It's not the quality of the film we're talking about here. The Worldwide box office has gone down considerably with every movie with the most recent F4 pulling in less than $170M WORLDWIDE. There's no reason to believe that just because Universal does a F4 film it would make money.
I mean, the quality of the film means you're bound to make a lot of money with good advertisement and word-of-mouth. I'm saying I don't see how Universal handling the F4 any more different than Sony and Fox and if it's good like Logan and Deadpool, then it's guaranteed to make money. It's just unfortunate Fox had some crappy writers and directors who were clueless about the F4 franchise. Unless Disney could alter the plans, the Dr. Doom movie is still in development after all and Constantin Film may have to sign with a new distributor with Disney or they won't and find somewhere else. Anything's possible.
I mean if it comes down to franchises, the reality is that most franchises are tired or played out..., what will happen to Star Wars in 10 years? What will happen to Marvel post-Infinity Wars when RDJ walks away?
Of course, those franchises won't die, but there will be serious fatigue, just as there is in Disney's own Pirates of the Caribbean. Harry Potter's Fantastic Beasts movies aren't quite as strong as the main series.
Disney itself isn't immune to franchise fatigue, it's just that they were smart to realize that Marvel and Lucasfilm had 2 major franchises/universes that hadn't been exploited in a significant fashion yet. The MCU works because it's a clean/fresh script that could be filled by RDJ and the rest. That won't be the case for the post-Thanos phases which will operate in a world where it's "already been done" and they're trying to carry a weighty franchise forward. A lot of the reason why things like GotG or Doctor Strange work is that they feel fresh compared to previous superhero movies.
That's one of the main reasons why the DCEU has largely failed... because Superman and Batman in particular have already received a large number of live action films and coming off of the Nolan trilogy, it was going to be hard to have that same impact with a new batman. They could only sell the "ensemble" idea one time before Justice League came and flopped. Sure they should have done a much better job of building up the universe with more introductory movies for Flash and Aquaman even before Batman vs Superman, but we'll have to see how well superhero movies hold up in the longer run once the first set of Avengers retires.
Rebooting X-Men isn't guaranteed to be successful either; I think it will work at some level to plug the hole of heroes leaving, but Fox has exploited that series pretty heavily the past 20 years and will go out with a last hurrah of a bunch of movies this upcoming year. Disney will have to be careful to weave it in in an interesting way similar to Spiderman Homecoming.
All of that said, franchises still have long-term value like Spiderman or James Bond or others. They can still be carried forward, but there's never a guarantee, that's a part of the reason why Fox is getting out of the business.
Universal's best shot at a major new franchise in the mid/longer run is these Nintendo rights if they can make that animated movie a big hit.
Disney has 26.09% market where the rest of the other big five members are lower than the 20% number, meaning they hire good directors and writers, but it does come with high-demands and ways none of the other studios have that luxury for. Universal-Nintendo animated movie deal is still a licensing deal, which is a common trend for Universal in both the film and theme park arena. It's no different than Disney having to license the video game characters for the Wreck-It-Ralph movie, and Disney isn't keen on getting 3rd world properties for their own movies and make a lot of money using its own IPs than to share money with a 3rd party company. As some people said here, I rather that Universal develop its own IPs rather than to have 3rd party companies, but nowadays, as I stated, that seems really hard for most studios except Disney.