The Creature is also drawn to the "other," just as the human scientists are drawn to the "other" from their perspective. The Bride is about as "other" as you can get.
Picture, if you will, a scenario where the Bride of Frankenstein is leading an expedition into the Black Lagoon in search of the escaped Gil Man, whose unique primordial biology promises to offer scientific secrets that she wishes to explore (perhaps something related to longevity - certainly a concern for someone born of deceased flesh). We board boats to help her map some uncharted territory and hopefully make some progress in locating the Creature. Before long, we find it -- or rather, Gil Man finds us -- and it's clear he's drawn to the Bride. Unfortunately, much like in the original film, the Creature interprets our presence as a threat to its own -- and crucially, its future with the Bride. The result is a climactic action sequence where the Creature attacks, and the Bride is forced to intervene and save us.
I have no idea if anything like that is happening. But if I were pitching, based on the concept implied by the Creature/Bride image in the existing Dark Universe merch, that's where I'd take it.