As opening day approaches, Feig can’t help but think about the stakes of making a $150 million movie. “A movie like this has to at least get to like $500 million worldwide, and that’s probably low,” he says. “But the thing I care about most is the industry looking for an excuse to say, ‘See, a tentpole can’t be carried by female leads’ ” — three of whom are over 40. “I cashed in all my chips,” he says. “I had to use every chip to make this happen. And if this doesn’t work, I will probably have to go back to movie jail.”