Considering Comcast, and Commercially; it would make sense that they could theoretically be in a bit of a rush for a new park, as while USF and IOA are great parks, they are limited on space.
This should, theoretically; give them more space for the future projects and while focusing on USF, IOA and Volcano are Important; theres more gain down south, especially with it being right next to the con space.
As for the Marvel brand, I think if we see it as it is now, and rising more and more; it shouldn't be a problem. But, they would most likely not use the MCU iterations for a IOA expansion of the Marvel Brand, and focus more on the modern comics.