To be honest, while I don't think Disney will "Disneify" Fox (because, look at what Lucasfilm and Marvel Entertainment has put out); but I do think they will have a reduced amount of films per year.
A reason why I think Comcast would've been good, primarily for IP's like Alien, Predator, Apes, Die Hard, Avatar; is that those are films that can lead to larger franchises; which is something Universal needs (Jurassic can't be the only major tent-pole). I feel they will lose some of that power when they go to Disney, and while I don't negate them not being used, I have a feeling there will be a lesser amount of those said films.
I can see the Disneyfication of the MCU movies quite a bit though. They are very generic and while good-hearted and well-thought out, has too much humor and have a straight storyline as well as being over-saturated. That's still old-school as it has for the past 50 years. They're purely designed and aimed to be kid-friendly. It's not gonna help the fact
Walt Disney Studios Motion Pictures is the main distributor of these movies, a studio known to be family and kid-friendly since 1953. Touchstone Pictures isn't used significantly recently, more importantly, since the last R-rated movie (and for the Mouse) Fright Night came out 7 years ago. So you could say Disney hasn't been on the R-rated trend since its acquisition of Marvel and Lucasfilm while other major studios within the Hollywood area continue to do so as normal. Looking at the first Iron Man film and TIH, both films tend to be violent and more serious with little to no humor in them, but since Disney bought up Marvel, they drive straight into the generic, bland humorous plot in order to increase merchandising among kids and families for the movie and theme parks.
Meanwhile, Fox started the popular R-rated CBM trend with Deadpool, a raunchy, hilarious, over-the-top violence Marvel movie and then did it again with Logan, a gritty, western-like setting from X-Men. Both movies are violent and have the tendency to say F-words and other things that wouldn't appear under the MCU. Even MCU TV shows, they don't go as far as saying the F-word and any of the thing like that, it seems good and basic and fits well with most of the cable drama shows. Some characters have some nude and butt scenes, but I don't think they go as far as what Deadpool does. Guarantee that X-Men would be incorporated into the MCU sooner or later, effectively terminating the Rated -R CMB movies, leaving Sony as the only hope to create an R-rated CMB for the Spider-Man universe.
Another problem is that Disney isn't known for allowing personal freedom regarding the MCU. Disney has a formula for its Marvel movies. They want them to be done in a very specific manner and directors just generally do not like working for the House of Mouse. Edgar Wright (Baby Driver, At World's End, Scott Pilgrim vs the World) was told he would get to make this cool heist film called Ant-Man. But once he began production, Disney and Marvel Studios executives started asking him to add in other heroes into the mix and to make sure there's a supervillain and to make sure it links into the Marvel Cinematic Universe. By the time it was all said and done, Ant-Man was a mess of a film. Edgar Wright left the project. Peyton Reed takes it over (whose biggest film by this point is
Bring it On). It starts off with that heist theme but then just transforms into the generic Marvel origins story (X-Hero faces off against the evil version of X-Hero).
In addition, Joss Whedon dropped out after Disney interfered with him on Age of Ultron. Whedon wanted to have the farmhouse scene in the movie (Hawkeye's awkward family scene). He was told he was only permitted to have that scene if he included an excursion for Thor in which he had a vision of the movie that would be 5 years away. Kenneth Branagh left Thor 2 after realizing he wouldn't be able to have his vision. He was replaced with Patty Jenkins who tried doing the job but felt that it was too constraining and she had creative differences with Disney. She said she would do a superhero movie, just she wants the reigns. Ava Duverney was offered to direct Black Panther. She turned down the job after meeting with Kevin Fiege who was sort of telling her what the story was about and where it would go and all this sort of stuff.
MCU is crafted and created by Marvel Studios and headed by Kevin Feige. For every script, scene, music, character, addition, ad-libs, fights, etc, all have to be reviewed and approved by Kevin Feige, nothing else. It's just one of the examples why I think Disney/Fox is a bad deal, in addition to those outside of the X-Men universe. Disney is the biggest mega-corporation of the whole United States and when they get big, it gives them more leverage in the entertainment industry.
None of those IPs, except Avatar, are tent pole blockbuster ones though. An Alien movie came out this year and didn't exactly set the world on fire, they're solid franchises but Universal can create new IPs that can draw as much as an Alien film could at this point. I'd prefer they go creative and fresh instead of buying properties.
As much as people would love to do that, it's hard to create a new IP that is fresh and appealing to the general audience than buying up existing properties and utilizing them to the same extent effectively. It's far few and between. And while Fox outside of X-Men, Avatar, and Planet of the Apes doesn't have as much appealing movie IPs recently, they still have shows that can attract Comcast easily. Shows like
American Horror Story (used twice for HHN),
The Simpsons,
Archer,
Family Guy,
American Dad,
Bob's Burger,
X-Files, and the like are something Universal lacks in the cable department. USA Network isn't that interesting anymore, as they show mostly law and order TV shows and nothing else. Universal is second in animation for the cinematic screen, but not great in animated TV shows. It's gotten so bad that Secret Life of Pets is nothing more than a ripoff off Toy Story, only with dogs instead of toys. There's a lot of ideas with an increased input of the Comcast/NBCUniversal deal with 21st Century Fox. Maybe not as much, but it does help them and would continue to allow personal freedoms for the directors who were denied a chance.