Bieber seems a lock. I expect usual riffs on superheroes, particularly Wonder Woman. Since the universe seems dead now, Tom Cruise's Mummy probably gets skewered hard. And there's no way they don't pay off 3 years of Avatar World jokes--Cameron and his sex tail have to show up. GMR/UoE closings probably come up as well.
Trump so radioactive right now (see "The Spirit" burning down WDWTragic before he leaves) I wonder if they might leave him out, go for an all happy, funny experience.