They already broke glass by bringing Skeet back for Scream 5. Are all these returning characters ghosts haunting Sidney, sending her into a psychotic break and making her the killer? Are they going a New Nightmare route where these performing actors are playing characters that are playing their characters in Stab? Does a new Ghostface attack a Comiccon where these actors are just doing dumb cameos as themselves at a panel? Does Scream 7 take place in the Afterlife because 7 rhymes with Heaven and everyone is dead? (That doesn't seem so bad, actually).
Scream works because it's so meta and because it's so meta, "death" is largely irrelevant.