I worry about Sony having too much say in this film. As much as people liked the ending of NWH, I immediately saw the whole "Nobody in the MCU remembers Peter Parker" thing as Disney/Sony hedging their bets in case another 2019 scuffle happens and they end up losing the rights.
Spider-Verse is only good because of the team behind it, and every other Sony Spider-Man project after Spider-Man 2 has been trash imo. The Multiverse is a dead concept before it ever actually got to live, and people are already tired of it. We've gotten 3 Spidey Multiverse films in the last 5 years, with a 4th on the horizon. Please no more of that. Secret Wars isn't gonna be special at all by the time it comes out because the MCU keeps trying to make the Endgame "Portals" scene happen every other day.
Make it a new story, no Symbiote, no Gwen or MJ, and if you cut ties with Pete's past in NWH, at least attempt to stick to it.
The MCU lost all of it's stakes as soon as they revived Vision in the first post-Endgame project only to never talk about him again. If they can't keep characters dead, at least try to move on from characters and stories you promised to literally forget. I like Ned and MJ, and I really liked their dynamic in Homecoming and FFH, but please stick to the story you promised in the last one.