Well....when people think Ghostbusters, they're going to instantly associate that IP with NY. If they build a GB everyone is going to expect it to be set in NY.
Let's say for the sake of argument that Spiderman at IoA never existed and the MCU Spiderman franchise hasn't gotten past Far From Home. If UO was heavily rumored to build a Spiderman ride, would it make any sense to have a Spiderman ride set in Europe? Everyone is going to expect it to be NY.
Yeah, I know we have WEB at DCA and that's where the illustration would fall apart, but you see what I'm saying. I can't imagine a proper GB E-ticket without it being set in its home city.