I think Shrek is safe for the next few years, for all the reasons
@GAcoaster outlined. I'll add that while I think it'd be great to have Despicable Me, Secret Life of Pets, and other similar properties all in one area together, I don't think it'd be wise for that to compose the entry area of USF, for a variety of operational and thematic reasons. Eventually I'd like to see "Production Central" and the soundstage aesthetic go away and Hollywood expanded through that area.
I'd like to see Shrek go, too, not because I dislike the franchise or anything, just because I think better can be done, both for that location and for a Shrek attraction elsewhere.