Pokemon sells merch like hot cakes. So if we're look at that, definitely profitable. A lot of people are into Pokemon but I think its in the way that people love collecting things.
A lot of the Pokemon are cute and work well as plush, candy, and things of the like. In US, I don't think long-term that an Anime event would continue to be profitable.
I have no doubt that Hollywood could work well with a couple food offerings, meet and greets, and maybe 1 walkthrough experience, and a small "roadshow".
Just like anime movies make a killing initially, sure they drop off after a while but it's honestly not like your average Horror Movie makes too much more with all-time earnings and we still see some of those represented at Horror Nights.
For example, Dragon Ball: Battle of Gods made around $51.2 in total earnings, worldwide. For comparision Insidious 2 made around $161m, This is The End made $50m but both were featured at HHN