Tonally, I think he could be great for CREATURE, which is the one I'd envision as slightly more of a horror/adventure fusion with some humor (though erring slightly more towards horror than Brendan Fraser's MUMMY, for example). Based on GET OUT and early word on US, Peele knows how to bring in laughs without undermining the horror stakes.
As for a FRANKENSTEIN adaptation, there's one name I saw thrown out by an online writer that I actually think would be a brilliant choice: Damien Chazelle. All three of his directorial efforts (WHIPLASH, LA LA LAND, and FIRST MAN) focus on very driven and emotionally-complicated men whose work either undermines or serves as an escape from their personal lives. I think that perfectly describes Victor Frankenstein.
Chazelle also wrote the underrated Hitchcockian thriller GRAND PIANO and co-wrote 10 CLOVERFIELD LANE, so he's got genre cred. And WHIPLASH was produced by... Jason Blum.