Either the show from Universal Singapore or updated Ghostbusters for Twister
Once the new museum opens, put some Lucy memorabilia there and use it and Shrek for the family dark ride (could be Universal Monsters themed). Use the cul-de-sac idea for KidZone to bring in some suburban IPs alongside E.T. (Coraline, TMNT, Scooby-Doo, the new Pets movie, Curious George maybe?), use Hill Valley 2015 as a transition to the new sci-fi area of the park. Star Trek, MIB and Doctor Who for the rest of the pad and World Expo. Fast and Furious for San Francisco.
You can then remove Beetlejuice and Horror Makeup Show since the monsters will have their own ride. Use both of those for new shows based on popular IPs. JAWS could return for the water park (SpongeBob and Minion Beach could be there potentially as well)
Monsters, Kong, BTTF, Jaws and Ghostbusters - all returning
biggest pipe dream ever
But Shrek should be torn down, while Twister could just get an overlay (not much you can do with that space)