I know a lot of people from Universal have been impressing upon us that this will be a farewell year for many icons and traditions, and I really do hope that they stick to their guns on it. I'm all for starting fresh and wouldn't mind if Jack, the Caretaker, the Usher, the Storyteller, and the Director were put into storage for a good while. Even under-utilized icons like Mary, Eddie, Cindy, Darkness, Terra Queen, etc. should probably take a break for now. Again, love'em all, but seeing new characters will be more exciting.
Old franchises and houses need to be concluded too. No more Psychoscareapy, Body Collectors, All Nite Die-In, Legendary Truth, Treaks, Chainsaw Drill Team, etc. Don't bring back Midway of the Bizarre, Deadtropolis, or whatever favorites fans may have.
Looking at HHNXX, there are some interesting ideas that could develop more in future years. Maybe HAVOC's Dogs of War can take to the streets. You could make a neat house out of the New Yorkshire setting from Saws 'n Steam. Don't know how Catacombs could come back, but I wouldn't mind it!
The most obvious new franchise would most likely be the continuing story of Z-Day from Zombiegeddon and Zombie Gras. I don't immediately recall HHN having a reaccuring zombie franchise, and it seems you could imagine some good houses or zones from seeing how Z-Day has affected various parts of the country.