Honestly, there's so many possibilites that I have to wonder how they'll incorporate Pokemon.
Part of what I'm most interested, is the art style. If they go more with the animated version, I somewhat hope it's a mixture of the more recent anime programs alongside the more recent mainline Pokemon titles (hell, even using the character styles seen in Pokemon Masters comes to mind as one potential angle of inspiration).
There's so much potential that this could go very interesting in many different ways.